Skip to main content
Skip to main menu


Adaptive Designs for Population Enrichment Strategy

Valdimir Dragalin
Janssen Pharmaceuticals, Johnson and Johnson
Cohel Room, Statistics Building

Population enrichment strategy offers a specific adaptive design methodology to study the effect of experimental treatments in various sub-populations of patients under investigation.  Instead of limiting the enrollment only to the enriched population, these designs enable the data-driven selection of one or more pre-specified subpopulations at an interim analysis and the confirmatory proof of efficacy in the selected subset at the end of the trial. In this presentation, the general hypothesis testing methodology and designing issues when planning such a design will be reviewed but the focus will be on the estimation of treatment effects after such adaptive tests.

Support us

We appreciate your financial support. Your gift is important to us and helps support critical opportunities for students and faculty alike, including lectures, travel support, and any number of educational events that augment the classroom experience. Click here to learn more about giving.

Every dollar given has a direct impact upon our students and faculty.