Tags: Colloquium Series

The Statistics Department hosts weekly colloquia on a variety of statistcal subjects, bringing in speakers from around the world.


Chris McMahan

Screening for sexually transmitted diseases has benefit ted greatly from the use of group testing (pooled testing) to lower costs. With the development of assays that detect multiple infections, screening practices now involve testing pools of individuals for multiple infections simultaneously. Building on the research for single infection group testing procedures, we examine the performance of group testing for multiple infections. Our work is…


Sun-Young Hwang

Various estimation methods in time series are reviewed in a unified framework via martingale estimating functions. In particular, maximum likelihood and quasi-likelihood are discussed in the context of asymptotic optimality within certain estimating functions. Both ergodic and non-ergodic processes are considered. To illustrate the main results, various parameter estimates for GARCH processes, bifurcating and explosive AR processes,…


Heping Zhang

In psychiatric and behavioral research, about six out of ten people with a substance use disorder suffer from another form of mental illness as well, making it necessary to consider multiple conditions as we study the etiologies of these conditions. The occurrence of multiple disorders in the same patient is referred to as comorbidity. Identifying the risk factors for comorbidity is an important yet difficult topic in psychiatric research. The…


Tianxi Cai

Clinical trials that evaluate treatment benefit focus primarily on estimating the average benefit. However, a treatment reported to be effective may not be beneficial to all patients. For example, the benefit of giving chemotherapy prior to hormone therapy with Tamoxifen in the adjuvant treatment of postmenopausal women with lymph node negative breast cancer depends on the ER-status. Due to the toxicity of chemotherapy, it is crucial to identify…


Jianhua Hu

For high dimensional genetic data, an important problem is to search for associations between genetic variables and a phenotype---typically, a discrete variable (diseased versus normal). A conventional solution is to characterize such relationships through regression models in which a phenotype is treated as the response variable and genetic variables are treated as the covariates. Not surprisingly, such a way incurs the challenging problem of…


Donglin Zeng

Dynamic treatment regimes (DTRs) are sequential decision rules for individual patients that can adapt over time to an evolving illness. Discovering DTRs from a SMART trial is challenging due to high-dimensional information and complex interactions between a patient's temporal characteristics and treatments. In this work, we introduce a new statistical learning method, namely outcome weighted learning (O-learning), for estimating the optimal DTR…


Guanqun Cao

We consider nonparametric estimation of the covariance function for dense functional data using computationally efficient tensor product B-splines. We develop both local and global asymptotic distributions for the proposed estimator, and show that our estimator is as efficient as an "oracle" estimator where the true mean function is known. Simultaneous confidence envelopes are developed based on asymptotic theory to quantify the variability in…


Chunming Zhang

The multiple testing procedure plays an important role in detecting the presence of spatial signals for large-scale imaging data. Typically, the spatial signals are sparse but clustered. This paper provides empirical evidence that for a range of commonly used control levels, the conventional FDR procedure can lack the ability to detect statistical significance, even if the p-values under the true null …


Runze Li

This paper is concerned with feature screening and variable selection for varying coefficient models with ultrahigh dimensional covariates. We propose a new feature screening procedure for these models based on conditional correlation coefficient. We systematically study the theoretical properties of the proposed procedure, and establish their sure screening property and the ranking consistency. To enhance the finite sample performance of the…


Peihua Qiu

In our daily life, we often need to identify individuals whose longitudinal patterns are different from the patterns of those well-functioning individuals, so that some unpleasant consequences can be avoided. In many such applications, observations of a given individual are obtained sequentially, and it is desirable to have a screening system to give a signal as soon as possible after that individual's longitudinal pattern starts to deviate from…
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